Any seasoned laboratorian knows it is incredibly unlikely that not one thing went wrong in a given laboratory for one month, let alone an entire quarter. Remediation of issues and continuous improvement can only occur once the organization recognizes the existence of NCEs and takes steps to eliminate their root causes. An effective NCE management program allows a laboratory to capture and tackle these issues in a systematic manner. In order to fully leverage your NCE management program, there are a few key steps that will position your lab for success.